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Average weight loss on phentermine 37.5 ±6.9 kg (17.1%) during treatment with 400 mg of metformin, 38, and 39.8±4.8 kg (15.7%-17.9%) following a 4-week period with 400-300 mg of metformin.39 When a 4-week treatment period followed short course of 100 mg metformin, subjects had higher weight loss of 40.0±3.5 and 39.3±3.8 kg respectively.41 The difference might be explained by lower body mass and higher fat content at baseline. The higher weight loss of phentermine vs metformin might be at least partially due to the fact that subjects had not been taking drugs for a long time and thus there had been a higher metabolic rate that contributed to the increased appetite.39 In conclusion, weight loss on phentermine with a short half-life, like other appetite suppressants metformin is associated with a normal body weight rebound in obese adults. The higher weight loss on phentermine may be partly responsible for the increased food intake of subjects. This study suggests that, after a period of weight loss, patients taking a milder dose of metformin should increase their dose of this drug if they experience an early weight rebound, especially in the first 4 weeks. Acknowledgement. The authors thank subjects for their participation in this research. References Schaefer KZ, Seftel H, Schiller R, Türker W, Baars J: The Phentermine Side Effect-Free Trial: efficacy of phentermine in primary care. J Clin Psychiatry 1997 Sep; 61(3):297-301. Schaefer KZ, Jager S, Schiller R, Türker W, Baars J: The Phentermine Side Effect-Free Trial: study characteristics and of success. Clinical Nutrition 2001 Jan; 11(1):13-22. Stahl W, Büchzel Schilthuizen J, Eichacker M, Schulz M (1995): Phentermine increases metabolic rate and appetite in post-obese hyperthyroid patients. International Journal of Obesity 21 (5), 511-518. Hoffman ML, Wachsmuth A, Albers JJ, Shuster I, Pendergrass RG, Rauchs-Luther K, Haffner S. (1995): Preexposure to the anorectic properties of metformin affects food intake, weight gain, leptin gene expression, and neuropeptide Y-receptor expression in humans. Physiol Behav 57 : 869-875. Briley PJ(1999): The effects of two doses metformin on weight and energy balance in individuals with obesity. dexamethason online bestellen Journal of Clinical Investigations 89(12):4033-4041. Lissner L, Dittrich H, Casperson P, Cauvel JB, Heid J, Gratz R. (1990): Phentermine reduces hunger and energy intake in lean obese children. International Journal of Obesity 11 : 1197-1203. Briley PJ, Schafer LA (1995): Effects of an alpha2 adrenergic antagonist, diphenhydramine, and a beta2 adrenergic antagonist, bupropion on appetite and food intake in humans with and without obesity. Human Psychopharmacology 1 : 133-137. Briley PJ, Schafer L (1995): Effects of an anorectic agent (dextroamphetamine) on food consumption, hunger and satiety in lean obese subjects. European Journal of Clinical Pharmacology 53 : 749-755. Shah M M, Khera S K, Prashanth K. (1993): Effects of alpha-2 adrenergic agonist and antagonist on food intake, body weight and appetite. The Indian Journal of Clinical Pharmacology 33 : 583-589. Schmader S T, Mittleman MA, Neely JV, Blum JH. (1993): Phentermine enhances satiety and best drugstore eyeliner uk reduces energy intake in obese women by inhibition of adenylate cyclase. International Journal Obesity 15 (12):1197-1205. Dumoulin C, Kneip T, Dehio Meller D. (1995): Effects of metformin on plasma leptin levels in healthy subjects. The Journal of Clinical Endocrinology and Metabolism 77 : 476-479. Dumoulin C, Delmotte G, Fournier Y-C, Meller D. (1995): Effects of metformin on plasma leptin levels in obese females. The International Journal of Obesity 12 : 1154-1160.
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